With the skeletal density measured by the AccuPyc included in the setup parameters for the envelope density, the GeoPyc will calculate and report the percent porosity and total pore volume of the ribbon. This information has proven to be useful in controlling the mechanical properties of the material, compression force settings on the roller compactor, and subsequent tablet press settings.
Pharmaceutical scientists realize that many of the physical, mechanical, and pharmacokinetics properties of tablets are influenced by the basic settings of a tablet press. Using the AccuPyc coupled with the GeoPyc, scientists are now able to determine quickly and easily the skeletal density, envelope density, total pore volume, percent porosity, and closed-cell pore volume of tablets produced with varying press settings.
Solid Fraction Data for Roller Compaction
Solid Fraction is a control parameter used in roller compaction operations. This control parameter assists in determining the optimal setting for speed, compression and nip angle in the roller compactor. Using the Solid Fraction as part of your SOP will ensure consistent product batch to batch, along with the end product having the designed and desired performance.